Scientific publications from SYNERGY

Joint effects between occupational exposures and smoking

  1. Olsson A, Bouaoun L, Schüz J, Vermeulen R, Behrens T, Ge C, et al. (2024). Lung cancer risks associated with occupational exposure to pairs of five lung carcinogens: results from a pooled analysis of case-control studies (SYNERGY). Environ Health Perspect. 132(1):17005. https://doi.org/10.1289/EHP13380 PMID:38236172

Exposure–response analyses in relation to lung cancer risk

  1. Wan W, Peters S, Portengen L, Olsson A, Schüz J, Ahrens W, et al. (2023). Occupational benzene exposure and lung cancer risk: a pooled analysis of 14 case-control studies. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.202306-0942OC PMID:37812782
  2. Behrens T, Ge C, Vermeulen R, Kendzia B, Olsson A, Schüz J, et al. (2023). Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY). Int J Cancer. 152(4):645–60. https://doi.org/10.1002/ijc.34272 PMID:36054442
  3. Olsson A, Guha N, Bouaoun L, Kromhout H, Peters S, Siemiatycki J, et al. (2022). Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: results from a pooled analysis of case-control studies (SYNERGY). Cancer Epidemiol Biomarkers Prev. 31(7):1433–41. https://doi.org/10.1158/1055-9965.EPI-21-1428 PMID:35437574
  4. Ge C, Peters S, Olsson A, Portengen L, Schüz J, Almansa J, et al. (2020). Respirable crystalline silica exposure, smoking, and lung cancer subtype risks. A pooled analysis of case-control studies. Am J Respir Crit Care Med. 202(3):412–21. https://doi.org/10.1164/rccm.201910-1926OC PMID:32330394
  5. Ge C, Peters S, Olsson A, Portengen L, Schüz J, Almansa J, et al. (2020). Diesel engine exhaust exposure, smoking, and lung cancer subtype risks. A pooled exposure-response analysis of 14 case-control studies. Am J Respir Crit Care Med. 202(3):402–11. https://doi.org/10.1164/rccm.201911-2101OC PMID:32330395
  6. Olsson AC, Vermeulen R, Schüz J, Kromhout H, Pesch B, Peters S, et al. (2017). Exposure-response analyses of asbestos and lung cancer subtypes in a pooled analysis of case-control studies. Epidemiology. 28(2):288–99. https://doi.org/10.1097/EDE.0000000000000604 PMID:28141674

Exposure assessment – the development of SYN-JEM

  1. Peters S, Vermeulen R, Portengen L, Olsson A, Kendzia B, Vincent R, et al. (2016). SYN-JEM: a quantitative job-exposure matrix for five lung carcinogens. Ann Occup Hyg. 60(7):795–811. https://doi.org/10.1093/annhyg/mew034 PMID:27286764
  2. Peters S, Kromhout H, Portengen L, Olsson A, Kendzia B, Vincent R, et al. (2013). Sensitivity analyses of exposure estimates from a quantitative job-exposure matrix (SYN-JEM) for use in community-based studies. Ann Occup Hyg. 57(1):98–106. https://doi.org/10.1093/annhyg/mes045 PMID:22805750
  3. Peters S, Vermeulen R, Olsson A, Van Gelder R, Kendzia B, Vincent R, et al. (2012). Development of an exposure measurement database on five lung carcinogens (ExpoSYN) for quantitative retrospective occupational exposure assessment. Ann Occup Hyg. 56(1):70–9. https://doi.org/10.1093/annhyg/mer081 PMID:21989165
  4. Peters S, Vermeulen R, Portengen L, Olsson A, Kendzia B, Vincent R, et al. (2011). Modelling of occupational respirable crystalline silica exposure for quantitative exposure assessment in community-based case-control studies. J Environ Monit. 13(11):3262–8. https://doi.org/10.1039/c1em10628g PMID:22001827

DOM-JEM and risk of lung cancer

  1. Peters S, Kromhout H, Olsson AC, Wichmann HE, Brüske I, Consonni D, et al. (2012). Occupational exposure to organic dust increases lung cancer risk in the general population. Thorax. 67(2):111–6. https://doi.org/10.1136/thoraxjnl-2011-200716 PMID:21856697
  2. Olsson AC, Gustavsson P, Kromhout H, Peters S, Vermeulen R, Brüske I, et al. (2011). Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. Am J Respir Crit Care Med. 183(7):941–8. https://doi.org/10.1164/rccm.201006-0940OC PMID:21037020

Job titles and risk of lung cancer

  1. Guha N, Bouaoun L, Kromhout H, Vermeulen R, Brüning T, Behrens T, et al. (2021). Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium. Occup Environ Med. 78(4):269–78. https://doi.org/10.1136/oemed-2020-106770 PMID:33115922
  2. Bigert C, Gustavsson P, Straif K, Taeger D, Pesch B, Kendzia B, et al. (2016). Lung cancer among firefighters: smoking-adjusted risk estimates in a pooled analysis of case-control studies. J Occup Environ Med. 58(11):1137–43. https://doi.org/10.1097/JOM.0000000000000878 PMID:27820764
  3. Consonni D, De Matteis S, Pesatori AC, Bertazzi PA, Olsson AC, Kromhout H, et al. (2015). Lung cancer risk among bricklayers in a pooled analysis of case-control studies. Int J Cancer. 136(2):360–71. https://doi.org/10.1002/ijc.28986 PMID:24861979
  4. Taeger D, Pesch B, Kendzia B, Behrens T, Jöckel KH, Dahmann D, et al. (2015). Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the SYNERGY pooled analysis of case-control studies. Scand J Work Environ Health. 41(5):467–77. https://doi.org/10.5271/sjweh.3513 PMID:26153779
  5. Bigert C, Gustavsson P, Straif K, Pesch B, Brüning T, Kendzia B, et al. (2015). Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China. J Occup Environ Med. 57(2):202–9. https://doi.org/10.1097/JOM.0000000000000337 PMID:25654522
  6. Behrens T, Kendzia B, Treppmann T, Olsson A, Jöckel KH, Gustavsson P, et al. (2013). Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study. Occup Environ Med. 70(11):810–4. https://doi.org/10.1136/oemed-2013-101469 PMID:23911873
  7. Kendzia B, Behrens T, Jöckel KH, Siemiatycki J, Kromhout H, Vermeulen R, et al. (2013). Welding and lung cancer in a pooled analysis of case-control studies. Am J Epidemiol. 178(10):1513–25. https://doi.org/10.1093/aje/kwt201 PMID:24052544
  8. Olsson AC, Xu Y, Schüz J, Vlaanderen J, Kromhout H, Vermeulen R, et al. (2013). Lung cancer risk among hairdressers: a pooled analysis of case-control studies conducted between 1985 and 2010. Am J Epidemiol. 178(9):1355–65. https://doi.org/10.1093/aje/kwt119 PMID:24068200

Social status and risk of lung cancer

  1. Hovanec J, Siemiatycki J, Conway DI, Olsson A, Stücker I, Guida F, et al. (2018). Lung cancer and socioeconomic status in a pooled analysis of case-control studies. PLoS One. 13(2):e0192999. https://doi.org/10.1371/journal.pone.0192999 PMID:29462211
  2. Hovanec J, Siemiatycki J, Conway DI, Olsson A, Guenel P, Luce D, et al. (2021). Application of two job indices for general occupational demands in a pooled analysis of case-control studies on lung cancer. Scand J Work Environ Health. 47(6):475–81. https://doi.org/10.5271/sjweh.3967 PMID:33942106
  3. Behrens T, Groß I, Siemiatycki J, Conway DI, Olsson A, Stücker I, et al. (2016). Occupational prestige, social mobility and the association with lung cancer in men. BMC Cancer. 16(1):395. https://doi.org/10.1186/s12885-016-2432-9 PMID:27388894

Smoking and risk of lung cancer

  1. Vlaanderen J, Portengen L, Schüz J, Olsson A, Pesch B, Kendzia B, et al. (2014). Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smoking and lung cancer in the SYNERGY Study. Am J Epidemiol. 179(3):290–8. https://doi.org/10.1093/aje/kwt273 PMID:24355332
  2. Pesch B, Kendzia B, Gustavsson P, Jöckel KH, Johnen G, Pohlabeln H, et al. (2012). Cigarette smoking and lung cancer – relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 131(5):1210–9. https://doi.org/10.1002/ijc.27339 PMID:22052329

External collaborations using SYNERGY’s epidemiological data or SYN-JEM

  1. Hall AL, Kromhout H, Schüz J, Peters S, Portengen L, Vermeulen R, et al. (2020). Laryngeal cancer risks in workers exposed to lung carcinogens: exposure-effect analyses using a quantitative job exposure matrix. Epidemiology. 31(1):145–54. https://doi.org/10.1097/EDE.0000000000001120 PMID:31577634
  2. Brenner DR, Fehringer G, Zhang ZF, Lee YA, Meyers T, Matsuo K, et al. (2019). Alcohol consumption and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. Cancer Epidemiol. 58:25–32. https://doi.org/10.1016/j.canep.2018.10.006 PMID:30445228
  3. Fehringer G, Brenner DR, Zhang ZF, Lee YA, Matsuo K, Ito H, et al. (2017). Alcohol and lung cancer risk among never smokers: a pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. Int J Cancer. 140(9):1976–84. https://doi.org/10.1002/ijc.30618 PMID:28120396